The study of metal complexes for the treatment of cancer diseases has resulted in the
identification of some unique properties of ruthenium-based compounds. Among these …

Since the discovery of cis-platinum, many transition metal complexes have been
synthesized and assayed for antineoplastic activity. In recent years, ruthenium-based …

Summary Background This phase I/II study determined the maximal tolerable dose, dose
limiting toxicities, antitumor activity, the pharmacokinetics and pharmacodynamics of …

Abstract Purpose: NAMI-A {H2Im [trans-RuCl4 (DMSO) HIm] or imidazolium-trans-DMSO-
imidazole-tetrachlororuthenate} is a novel ruthenium-containing compound that has …

The antitumor activity of the organometallic ruthenium (II)− arene complexes, RuCl2 (η6-
arene)(PTA),(arene= p-cymene, toluene, benzene, benzo-15-crown-5, 1-ethylbenzene-2, 3 …

Based on the clinical success of platinum-based anti-cancer drugs such as cisplatin,
carboplatin and oxaliplatin, a variety of other metal-based anti-cancer compounds are being …

Inhibition of the growth of the human ovarian cancer cell line A2780 by organometallic
ruthenium (II) complexes of the type [(η6-arene) Ru (X)(Y)(Z)], where arene is benzene or …

1, 2, 4-triazole is an important nucleus present in a large number of compounds. More than
thirty-five compounds containing this nucleus are introduced into the market. 1, 2, 4-triazole …

The mortality rates from various tumor types can be reduced dramatically by use of highly
active drugs. This is particularly true for platinum-based drugs, being among the most …

Cancer chemotherapy is almost always applied to patients with one or more diagnosed
metastases and is expected to impact these lesions, thus providing significant benefits to the …