Update on the pathogenesis of vitiligo
HZ Marchioro, CCS Castro, VM Fava… - Anais Brasileiros de …, 2022 - SciELO Brasil
Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …
Melanogenesis and the targeted therapy of melanoma
C Li, L Kuai, R Cui, X Miao - Biomolecules, 2022 - mdpi.com
Pigment production is a unique character of melanocytes. Numerous factors are linked with
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …
Melanoma and vitiligo: in good company
CM Failla, ML Carbone, C Fortes, G Pagnanelli… - International Journal of …, 2019 - mdpi.com
Cutaneous melanoma represents the most aggressive form of skin cancer, whereas vitiligo
is an autoimmune disorder that leads to progressive destruction of skin melanocytes …
is an autoimmune disorder that leads to progressive destruction of skin melanocytes …
Advances in vitiligo: Update on therapeutic targets
Y Feng, Y Lu - Frontiers in immunology, 2022 - frontiersin.org
Vitiligo, whose treatment remains a serious concern and challenge, is an autoimmune skin
disease characterized by patches of depigmentation. The increasing application of …
disease characterized by patches of depigmentation. The increasing application of …
The essential role of micrornas in inflammatory and autoimmune skin diseases—a review
K Dopytalska, A Czaplicka, E Szymańska… - International Journal of …, 2023 - mdpi.com
The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood.
The role of epigenetic factors is emphasized in the development of such diseases …
The role of epigenetic factors is emphasized in the development of such diseases …
Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo
HY Abdallah, NR Abdelhamid, EA Mohammed… - Scientific Reports, 2022 - nature.com
Vitiligo is considered a disabling disease that affects physical, social, psychological, and
occupational aspects of an individual's quality of life. The search for non-invasive and …
occupational aspects of an individual's quality of life. The search for non-invasive and …
[HTML][HTML] SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/β-catenin signaling
DP Zou, YM Chen, LZ Zhang, XH Yuan, YJ Zhang… - Genes & diseases, 2021 - Elsevier
Secreted frizzled-related protein 5 (SFRP5) plays a pivotal role in regulating the
development of many tissues and organs, however, as an inhibitor of Wnt signaling, the role …
development of many tissues and organs, however, as an inhibitor of Wnt signaling, the role …
Epigenetic dysregulation in autoimmune and inflammatory skin diseases
F Gibson, A Hanly, N Grbic, N Grunberg, M Wu… - Clinical Reviews in …, 2022 - Springer
Epigenetics is the study of heritable, reversible gene expression patterns that do not
originate from alterations in the DNA sequence. Epigenetic modifications influence gene …
originate from alterations in the DNA sequence. Epigenetic modifications influence gene …
Trained immunity in the pathogenesis of vitiligo
NF Post, G Ginski, R Peters… - Pigment cell & …, 2023 - Wiley Online Library
Vitiligo is caused by an autoimmune reaction against melanocytes leading to melanocyte
loss. The cause of vitiligo is an interaction between genetic susceptibility and environmental …
loss. The cause of vitiligo is an interaction between genetic susceptibility and environmental …
Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human …
MH Aguennouz, F Guarneri, R Oteri, F Polito… - Journal of …, 2021 - Elsevier
Background Epigenetics of vitiligo was evaluated in few studies. In particular, the role of miR-
21, a microRNA involved in various processes, including melanogenesis, was never …
21, a microRNA involved in various processes, including melanogenesis, was never …