Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …

Pigment production is a unique character of melanocytes. Numerous factors are linked with
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …

Cutaneous melanoma represents the most aggressive form of skin cancer, whereas vitiligo
is an autoimmune disorder that leads to progressive destruction of skin melanocytes …

Vitiligo, whose treatment remains a serious concern and challenge, is an autoimmune skin
disease characterized by patches of depigmentation. The increasing application of …

The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood.
The role of epigenetic factors is emphasized in the development of such diseases …

Vitiligo is considered a disabling disease that affects physical, social, psychological, and
occupational aspects of an individual's quality of life. The search for non-invasive and …

Secreted frizzled-related protein 5 (SFRP5) plays a pivotal role in regulating the
development of many tissues and organs, however, as an inhibitor of Wnt signaling, the role …

Epigenetics is the study of heritable, reversible gene expression patterns that do not
originate from alterations in the DNA sequence. Epigenetic modifications influence gene …

Vitiligo is caused by an autoimmune reaction against melanocytes leading to melanocyte
loss. The cause of vitiligo is an interaction between genetic susceptibility and environmental …

Background Epigenetics of vitiligo was evaluated in few studies. In particular, the role of miR-
21, a microRNA involved in various processes, including melanogenesis, was never …