Autoimmune diseases are a broad spectrum of human diseases that are characterized by
the breakdown of immune tolerance and the production of autoantibodies. Recently …

Lysosomal storage diseases are usually considered to be pathologies in which the passive
deposition of unwanted materials leads to functional changes in lysosomes. Lysosomal …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

Increasing incidences of obesity and diabetes have made diabetic kidney disease (DKD) the
leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite …

Review summarizes the evidence supporting the existence of endogenous ligands of TLR2
and TLR4 and proposes that many may be better described as PAMP-sensitizing molecules …

The innate immune system is the first line of defense in response to nonself and danger
signals from microbial invasion or tissue injury. It is increasingly recognized that each organ …

Renal inflammation is a universal response to infectious and noninfectious triggers. Sensors
of the innate immune system, such as Toll-like receptors or RIG-like receptors, provide …

The response to exogenous pathogens leads to activation of innate immunity through the
release of pathogen-associated molecular patterns (PAMPs) and their binding to pattern …

Accumulating evidence indicates that inflammatory and immunologic processes play a
significant role in the development and progression of glomerular diseases. Podocytes, the …