Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
Vaccines and drugs have helped reduce disease severity and blunt the spread of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus …
Functions of coronavirus accessory proteins: overview of the state of the art
P Fang, L Fang, H Zhang, S Xia, S Xiao - Viruses, 2021 - mdpi.com
Coronavirus accessory proteins are a unique set of proteins whose genes are interspersed
among or within the genes encoding structural proteins. Different coronavirus genera, or …
among or within the genes encoding structural proteins. Different coronavirus genera, or …
Immune response against SARS-CoV-2 variants: the role of neutralization assays
AM Chmielewska, A Czarnota… - Npj Vaccines, 2021 - nature.com
Since the emergence of the novel coronavirus SARS-CoV-2 in late 2019, the COVID-19
pandemic has hindered social life and global economic activity. As of July 2021, SARS-CoV …
pandemic has hindered social life and global economic activity. As of July 2021, SARS-CoV …
In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2
Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small
molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports …
molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports …
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses
The current COVID-19 pandemic is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the viral RNA …
coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the viral RNA …
[HTML][HTML] The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera.
One year in the coronavirus disease 2019 (COVID-19) pandemic, the first vaccines are
being rolled out under emergency use authorizations. It is of great concern that newly …
being rolled out under emergency use authorizations. It is of great concern that newly …
Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 human ACE2 transgenic mice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the viral pathogen
responsible for the current coronavirus disease 2019 (COVID-19) pandemic. As of 19 May …
responsible for the current coronavirus disease 2019 (COVID-19) pandemic. As of 19 May …
Selection of a SARS-CoV-2 surrogate for use in surface disinfection efficacy studies with chlorine and antimicrobial surfaces
Initial recommendations for surface disinfection to prevent SARS-CoV-2 transmission were
developed using previous evidence from potential surrogates. To the best of our knowledge …
developed using previous evidence from potential surrogates. To the best of our knowledge …
Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
current COVID-19 pandemic, is one of the biggest threats to public health. However, the …
current COVID-19 pandemic, is one of the biggest threats to public health. However, the …
Reverse genetic systems of SARS-CoV-2 for antiviral research
Reverse genetic systems are widely used to engineer recombinant viruses with desired
mutations. In response to the COVID-19 pandemic, four types of reverse genetic systems …
mutations. In response to the COVID-19 pandemic, four types of reverse genetic systems …