Bioluminescence imaging: looking beyond the light

M Keyaerts, V Caveliers, T Lahoutte - Trends in molecular medicine, 2012 - cell.com
Bioluminescence imaging (BLI) enables in vivo imaging of molecular and cellular
processes. It has gained in popularity over the past decade because of its easy translation …

Bioluminescence imaging: basics and practical limitations

CE Badr - Bioluminescent Imaging: Methods and Protocols, 2014 - Springer
Over the last three decades, imaging has been a thriving field with continuous egression of
more reliable and highly sophisticated tools and techniques allowing better understanding …

ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells

JM Drake, G Strohbehn, TB Bair… - Molecular biology of …, 2009 - Am Soc Cell Biol
Metastatic colonization involves cancer cell lodgment or adherence in the microvasculature
and subsequent migration of those cells across the endothelium into a secondary organ site …

Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth

BR James, A Tomanek-Chalkley… - The Journal of …, 2012 - journals.aai.org
Obesity is a mounting health concern in the United States and is associated with an
increased risk for developing several cancers, including renal cell carcinoma (RCC) …

In vivo therapeutic silencing of hypoxia-inducible factor 1 alpha (HIF-1α) using single-walled carbon nanotubes noncovalently coated with siRNA

G Bartholomeusz, P Cherukuri, J Kingston, L Cognet… - Nano research, 2009 - Springer
A new approach is described for delivering small interfering RNA (siRNA) into cancer cells
by noncovalently complexing unmodified siRNA with pristine single-walled carbon …

A pilot study to determine the optimal dose of scAAVIL-1ra in a large animal model of post-traumatic osteoarthritis

P Thampi, KA Seabaugh, LM Pezzanite, CR Chu… - Gene Therapy, 2023 - nature.com
Gene therapy approaches using adeno-associated viral vectors have been successfully
tested in the equine post-traumatic osteoarthritis (PTOA) model. Owing to differences in the …

Epigenetic reprogramming governs EcSOD expression during human mammary epithelial cell differentiation, tumorigenesis and metastasis

ML Teoh-Fitzgerald, MP Fitzgerald, W Zhong… - Oncogene, 2014 - nature.com
Expression of the antioxidant enzyme EcSOD in normal human mammary epithelial cells
was not recognized until recently. Although expression of EcSOD was not detectable in non …

Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury

B Dukay, FR Walter, JP Vigh, B Barabási… - Journal of …, 2021 - Springer
Background Heat-shock protein B1 (HSPB1) is among the most well-known and versatile
member of the evolutionarily conserved family of small heat-shock proteins. It has been …

Gene therapy for osteoarthritis: pharmacokinetics of intra-articular self-complementary adeno-associated virus interleukin-1 receptor antagonist delivery in an equine …

RS Watson Levings, TA Broome, AD Smith… - Human gene therapy …, 2018 - liebertpub.com
Toward the treatment of osteoarthritis (OA), the authors have been investigating self-
complementary adeno-associated virus (scAAV) for intra-articular delivery of therapeutic …

Real-time monitoring of nuclear factor κB activity in cultured cells and in animal models

CE Badr, JM Niers, LA Tjon-Kon-Fat… - Molecular …, 2009 - journals.sagepub.com
Nuclear factor κB (NF-κB) is a transcription factor that plays a major role in many human
disorders, including immune diseases and cancer. We designed a reporter system based on …