Targeting cancer metabolism in the era of precision oncology
One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
[HTML][HTML] Lipid metabolism and cancer
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion
N Jiang, B Xie, W Xiao, M Fan, S Xu, Y Duan… - Nature …, 2022 - nature.com
Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25%
one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial …
one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial …
[PDF][PDF] Greasing the wheels of the cancer machine: the role of lipid metabolism in cancer
MT Snaebjornsson, S Janaki-Raman, A Schulze - Cell metabolism, 2020 - cell.com
Altered lipid metabolism is among the most prominent metabolic alterations in cancer.
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …
Mitochondrial copper depletion suppresses triple-negative breast cancer in mice
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and
reduces energy production, is known to be effective against cancer types that depend on …
reduces energy production, is known to be effective against cancer types that depend on …
[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
[PDF][PDF] Targeting DGAT1 ameliorates glioblastoma by increasing fat catabolism and oxidative stress
Glioblastoma (GBM), a mostly lethal brain tumor, acquires large amounts of free fatty acids
(FAs) to promote cell growth. But how the cancer avoids lipotoxicity is unknown. Here, we …
(FAs) to promote cell growth. But how the cancer avoids lipotoxicity is unknown. Here, we …
[PDF][PDF] Aging and rejuvenation of neural stem cells and their niches
Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …
declining cognitive function and enhanced risk of brain diseases, including cancer and …
Altered cellular metabolism in gliomas—An emerging landscape of actionable co-dependency targets
Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …
technological advances, new insights into the molecular mechanisms underlying glioma …
The diversity and breadth of cancer cell fatty acid metabolism
Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …
biomass synthesis while maintaining redox balance and cellular homeostasis. These …