Two-dimensional gel electrophoresis was instrumental in the birth of proteomics in the late
1980s. However, it is now often considered as an outdated technique for proteomics—a …

Post-translational modification of the adeno-associated virus capsids is a poorly understood
factor in the development of these viral vectors into pharmaceutical products. Here we report …

This review outlines the latest findings on bioconjugation using lipoic acid ligase A (LplA), a
key enzyme that allows the introduction of new functional groups into biomolecules. LplA …

The protein corona is widely recognized as a key concept in contemporary nanomedicine. In
recent years, the interest in the protein corona has reached new heights as a number of …

Aims Although trastuzumab (TZB)-induced cardiotoxicity is well documented and allicin (one
of the main active garlic ingredients) has ameliorating effects against numerous causes of …

For several decades, a plant‐based expression system has been proposed as an alternative
platform for the production of biopharmaceuticals including therapeutic monoclonal …

Antibody-drug conjugates (ADC) represent an emerging, novel class of biopharmaceuticals.
The heterogeneity originating from the sophisticated structure requires orthogonal analytical …

Use of monoclonal antibodies is emerging as a highly promising and fast-developing
scenario for innovative treatment of viral, autoimmune and tumour diseases. The search for …

Regulatory agencies establish that a broad physicochemical and biological characterization
is necessary for the evaluation of comparability between a biosimilar candidate product and …

Purpose To understand non-enzymatic hydrolytic fragmentation of a monoclonal antibody
therapeutic under temperature stressed conditions and investigating possible mechanism …