Medicinal chemistry of isocyanides

A Massarotti, F Brunelli, S Aprile, M Giustiniano… - Chemical …, 2021 - ACS Publications
In eons of evolution, isocyanides carved out a niche in the ecological systems probably
thanks to their metal coordinating properties. In 1859 the first isocyanide was synthesized by …

Multicomponent reaction toolbox for peptide macrocyclization and stapling

L Reguera, DG Rivera - Chemical reviews, 2019 - ACS Publications
In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …

To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis

M Giustiniano, A Basso, V Mercalli… - Chemical Society …, 2017 - pubs.rsc.org
The term functionalized isocyanides refers to all those isocyanides in which a neighbouring
functional group can finely tune the reactivity of the isocyano group or can be exploited in …

Metal-mediated and metal-catalyzed reactions of isocyanides

VP Boyarskiy, NA Bokach, KV Luzyanin… - Chemical …, 2015 - ACS Publications
1. INTRODUCTION A timely subtitle to this Review focused on conversions of isocyanides at
metal centers could have been “a platinum jubilee of the first metal-mediated reaction …

Transition metal-mediated synthesis of monocyclic aromatic heterocycles

AV Gulevich, AS Dudnik, N Chernyak… - Chemical …, 2013 - ACS Publications
Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles | Chemical Reviews
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …

Probing the electronic and catalytic properties of a bimetallic surface with 3 nm resolution

JH Zhong, X Jin, L Meng, X Wang, HS Su… - Nature …, 2017 - nature.com
An atomic-and molecular-level understanding of heterogeneous catalysis is required to
characterize the nature of active sites and improve the rational design of catalysts …

Formal [4+ 1] annulation reactions in the synthesis of carbocyclic and heterocyclic systems

JR Chen, XQ Hu, LQ Lu, WJ Xiao - Chemical reviews, 2015 - ACS Publications
The development of new strategies and chemical reactions continues to be a major focus of
research efforts in the modern synthetic organic community. 1 Of the various types of …

Metal-catalyzed C–H functionalization involving isocyanides

B Song, B Xu - Chemical Society Reviews, 2017 - pubs.rsc.org
Isocyanides have a broad range of applications in multicomponent reactions such as
Passerini and Ugi processes. Recent advances in metal catalysis have tremendously …

Palladium‐catalyzed migratory insertion of isocyanides: an emerging platform in cross‐coupling chemistry

T Vlaar, E Ruijter, BUW Maes… - Angewandte Chemie …, 2013 - Wiley Online Library
Isocyanides have been important building blocks in organic synthesis since the discovery of
the Ugi reaction and related isocyanide‐based multicomponent reactions. In the past …

Toward the generation of 2-amino-3-formyl difunctionalized chromones via Pd-enabled rearrangement strategy

Q Tong, RF Xiu, JH Chen, Y Zhang, BD Cui… - ACS …, 2023 - ACS Publications
Accomplished herein is a rearrangement strategy for the highly efficient assembly of
synthetically cumbersome while medicinally significant 2-amino-3-formyl chromones via …