Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …

Malaria is a major public health burden throughout the world. Resistance to the antimalarial
drugs has increased the mortality and morbidity rate that is achieved so far through the …

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …

Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …

Resistance to antimalarial drugs has often threatened malaria elimination efforts and
historically has led to the short-term resurgence of malaria incidences and deaths. With …

The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria
parasites has been a disaster for world health. Resistance is conferred by mutations in the …

The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor
to multidrug resistance and is also essential for the survival of the malaria parasite, yet its …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials,
chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health …

Despite intensive research extending back to the 1930s, when the first synthetic antimalarial
drugs made their appearance, the repertoire of clinically licensed formulations remains very …