In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Immune checkpoint inhibitors have revolutionized medical oncology, although currently only
a subset of patients has a response to such treatment. A compelling body of evidence …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Angiogenesis is defined as the formation of new blood vessels from preexisting vessels and
has been characterized as an essential process for tumor cell proliferation and viability. This …

Simple Summary Cancer is one of the hardest pathologies to fight, being one of the main
causes of death worldwide despite the constant development of novel therapeutic strategies …

Tumour angiogenesis is a fast growing domain in tumour biology. Many growth factors and
mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of …

Glioblastoma is one of the most angiogenic human tumours and endothelial proliferation is a
hallmark of the disease. A better understanding of glioblastoma vasculature is needed to …

The cellular origin of Ewing tumor (ET), a tumor of bone or soft tissues characterized by
specific fusions between EWS and ETS genes, is highly debated. Through gene expression …

Tumor cell vasculogenic mimicry (VM) describes the functional plasticity of aggressive
cancer cells forming de novo vascular networks, thereby providing a perfusion pathway for …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …