The discovery of antibiotics has created a turning point in medical interventions to
pathogenic infections, but unfortunately, each discovery was consistently followed by the …

Vancomycin-resistant enterococci (VRE) are both of medical and public health importance
associated with serious multidrug-resistant infections and persistent colonization …

The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the
treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind …

Phosphorus-containing drugs belong to an important class of therapeutic agents and are
widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can …

Prodrug design is a widely known molecular modification strategy that aims to optimize the
physicochemical and pharmacological properties of drugs to improve their solubility and …

Staphylococcus aureus, although generally identified as a commensal, is also a common
cause of human bacterial infections, including of the skin and other soft tissues, bones …

Staphylococcus aureus is an important human pathogen that causes wide range of
infectious conditions both in nosocomial and community settings. The Gram-positive …

Antibiotic resistance is a global health issue and a potential risk for society. Antibiotics
administered through conventional formulations are devoid of targeting effect and often …

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) result in significant
morbidity and mortality for patients in both community and health care settings. This is …

Despite the undisputed development of medicine, antibiotics still serve as first-choice drugs
for patients with infectious disorders. The widespread use of antibiotics results from a wide …