Numerous studies have reported significant associations between ABO blood group and risk
of cardiovascular disease. These studies have consistently demonstrated that thrombotic …

Platelet refractoriness can represent a significant clinical problem that complicates the
provision of platelet transfusions, is associated with adverse clinical outcomes and …

. ABO histo‐blood group is a major determinant of plasma levels of factor VIII (FVIII) and von
Willebrand factor (vWF). Blood group O individuals have significantly (approximately 25%) …

To date, 33 human platelet alloantigens (HPA s) have been identified on six functionally
important platelet glycoprotein (GP) complexes and have been implicated in alloimmune …

Neonatal alloimmune thrombocytopenia,(NAIT) is caused by maternal antibodies raised
against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a …

Enzymes catalyze biochemical reactions and play critical roles in human health and
disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which …

Platelet transfusion is a common practice in onco-hematologic patients for preventing or
treating hemorrhages. Platelet concentrates can be transfused with therapeutic or …

ABO blood groups have been associated with various disease phenotypes, particularly
cardiovascular diseases. Cardiovascular diseases are the most common causes of death in …

Platelets express ABO antigens and are collected in plasma, which contains ABO antibodies
as would be consistent with the donor ABO group. Platelet ABO antigens that are …

Abstract Background Platelet glycoprotein (GP) Ibα is the major ligand-binding subunit of the
GPIb-IX-V complex that binds von Willebrand factor. GPIbα is heavily glycosylated, and its …