The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Molecular mechanisms of epithelial–mesenchymal transition

S Lamouille, J Xu, R Derynck - Nature reviews Molecular cell biology, 2014 - nature.com
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Z Huang, Z Zhang, C Zhou, L Liu, C Huang - MedComm, 2022 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Emerging genotype–phenotype relationships in patients with large NF1 deletions

H Kehrer-Sawatzki, VF Mautner, DN Cooper - Human Genetics, 2017 - Springer
The most frequent recurring mutations in neurofibromatosis type 1 (NF1) are large deletions
encompassing the NF1 gene and its flanking regions (NF1 microdeletions). The majority of …

Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs

S Lamouille, D Subramanyam, R Blelloch… - Current opinion in cell …, 2013 - Elsevier
Epithelial–mesenchymal transition (EMT) and the reverse process, mesenchymal–epithelial
transition (MET), are essential during development and in the regulation of stem cell …

Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives

A Díaz-López, G Moreno-Bueno… - Cancer management and …, 2014 - Taylor & Francis
The microRNAs (miRNAs) are a class of small, 20–22 nucleotides in length, endogenously
expressed noncoding RNAs that regulate multiple targets posttranscriptionally. Interestingly …

HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development

L Zhou, Y Wang, M Zhou, Y Zhang, P Wang, X Li… - Nature …, 2018 - nature.com
Glycolytic reprogramming is a typical feature of many cancers; however, key regulators of
glucose metabolism reengineering are poorly understood, especially in cutaneous …

NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression

T Yamaguchi, Y Hosono, K Yanagisawa, T Takahashi - Cancer cell, 2013 - cell.com
Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also
known as TTF-1, plays a role as a" lineage-survival" oncogene in lung adenocarcinomas. In …

The role of MicroRNA in the regulation of tumor epithelial–mesenchymal transition

J Feng, S Hu, K Liu, G Sun, Y Zhang - Cells, 2022 - mdpi.com
Consistently, the high metastasis of cancer cells is the bottleneck in the process of tumor
treatment. In this process of metastasis, a pivotal role is executed by epithelial …

Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions

F Guo, BC Parker Kerrigan, D Yang, L Hu… - Journal of hematology & …, 2014 - Springer
Epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-
epithelial transition (MET), play important roles in embryogenesis, stem cell biology, and …