Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune
response in a very complex and flowery manner. The history of host-parasite co-evolution …

Cytokine members of the IL‐12 family have attracted enormous attention in the last few
years, with IL‐35 being the one of the most attractive‐suppressive cytokine. IL‐35 is an …

Rationale: Polymorphisms on chromosome 17q21 confer the major genetic susceptibility to
childhood-onset asthma. Risk alleles positively correlate with ORMDL3 (orosomucoid-like 3) …

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects
over 8 million people worldwide. In spite of a powerful innate and adaptive immune …

The protozoan Trypanosoma cruzi is the causative agent of Chagas' disease, endemic in
Latin America but present worldwide. Research efforts have focused on the examination of …

Cyclic AMP (cAMP) is involved in many biological processes but little is known regarding its
role in shaping immunity. Here we show that cAMP-PKA-CREB signaling (a pattern …

Arginase-1 (Arg-1) is a marker for alternatively activated macrophages (AAM) and is mainly
induced by the type 2 cytokines interleukin (IL)-4 and IL-13 through the common IL-4 …

The identification of anti-inflammatory mediators can reveal important targetable molecules
capable of counterbalancing Trypanosoma cruzi-induced myocarditis. Composed of Ebi3 …

Mesenchymal stem cells (MSC) can differentiate into chondrocytes. Epstein–Barr virus-
induced gene 3 (EBI3) is differentially expressed during chondrogenic differentiation and …

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time,
and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of …