Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development,
tumorigenesis, and pluripotency, but their exact functions are poorly understood. Here, we …

Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and
oncogenesis. Poorly differentiated, aggressive cancers often overexpress Lin28, but its role …

Human LIN28A and LIN28B are RNA-binding proteins (RBPs) conserved in animals with
important roles during development and stem cell reprogramming. We used …

Lin28 is an essential RNA-binding protein that is ubiquitously expressed in embryonic stem
cells. Its physiological function has been linked to the regulation of differentiation …

In the past two decades, microRNAs have emerged as crucial mediators of organ
development and human disease. Here, we discuss their role as drivers or suppressors of …

Beginning with their discovery in the context of stem cell fate choice in Caenorhabditis
elegans, the microRNA (miRNA) let-7 and the RNA-binding protein Lin28 have been …

Abstract The Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common
human cancer, causing 350,000 individuals die worldwide each year. The overall prognosis …

An RNA-binding protein, LIN28A was initially discovered in nematodes Caenorhabditis
elegans and regulated stem cell differentiation and proliferation. With the aid of mouse …