The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …

Abstract TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases
that have important effects on hemostasis and inflammation. Also, they affect cell …

Mer tyrosine kinase (MerTK) is a major macrophage apoptotic cell (AC) receptor. Its
functional impairment promotes autoimmunity and atherosclerosis, whereas overexpression …

MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in
myeloid lineage cells in which it acts to suppress proinflammatory cytokines following …

Tuberculosis remains a common and dangerous chronic bacterial infection worldwide. It is
long-established that pathogenesis of many autoimmune diseases is mainly promoted by …

Failure to efficiently clear apoptotic cells is linked to defects in development and the onset of
autoimmunity. Complement component C1q is required for efficient engulfment of apoptotic …

Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for
tissue homeostasis. Professional phagocytes express a plethora of surface receptors …

Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous
system affecting over 2 million people worldwide. The TAM family of receptor tyrosine …

Objective The purpose of this study is to determine whether TAM receptors and ligands
associated with the activity and severity of lupus nephritis. Methods Clinical data were …

Receptor tyrosine kinases, Tyro-3, Axl and Mer, collectively designated as TAM, are involved
in the clearance of apoptotic cells. TAM ligands, Gas6 and Protein S, bind to the surfaces of …