Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response
SR McKeown - The British journal of radiology, 2014 - academic.oup.com
Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …
as it compromises treatment and drives malignant progression. This review seeks to clarify …
The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities
C WalshJoseph, C KolbHartmuth - Antioxidants & redox signaling, 2014 - liebertpub.com
Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …
Detection and Characterization of Tumor Hypoxia Using pO2 Histography
P Vaupel, M Höckel, A Mayer - Antioxidants & redox signaling, 2007 - liebertpub.com
Data from 125 studies describing the pretreatment oxygenation status as measured in the
clinical setting using the computerized Eppendorf pO2 histography system have been …
clinical setting using the computerized Eppendorf pO2 histography system have been …
Pancreatic tumors show high levels of hypoxia
Purpose: Because of the dismal outcomes of conventional therapies for pancreatic
carcinomas, we postulated that hypoxia may exist within these tumors. Methods and …
carcinomas, we postulated that hypoxia may exist within these tumors. Methods and …
Treatment resistance of solid tumors: role of hypoxia and anemia
P Vaupel, O Thews, M Hoeckel - Medical oncology, 2001 - Springer
Hypoxia is a characteristic property of locally advanced solid tumors, resulting from an
imbalance between the supply and consumption of oxygen. Major pathogenetic …
imbalance between the supply and consumption of oxygen. Major pathogenetic …
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
JL Tatum - International journal of radiation biology, 2006 - Taylor & Francis
Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …
workshop to assess the current status of hypoxia imaging, to assess what is known about the …
Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer
Purpose: Tumor hypoxia is an important determinant of outcome in many human
malignancies and is associated with treatment resistance and metastases. The aim of this …
malignancies and is associated with treatment resistance and metastases. The aim of this …
Hypoxia-driven selection of the metastatic phenotype
R Sullivan, CH Graham - Cancer and Metastasis Reviews, 2007 - Springer
Intratumoral hypoxia is an independent indicator of poor patient outcome and increasing
evidence supports a role for hypoxia in the development of metastatic disease. Studies …
evidence supports a role for hypoxia in the development of metastatic disease. Studies …
Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy?
L Harrison, K Blackwell - The oncologist, 2004 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Explain
how tumor hypoxia affects radiation resistance. Apply this understanding to clinical outcome …
how tumor hypoxia affects radiation resistance. Apply this understanding to clinical outcome …
Prodrug strategies in cancer therapy
WA Denny - European journal of medicinal chemistry, 2001 - Elsevier
Systemic cytotoxic (anti-proliferative) anticancer drugs rely primarily for their therapeutic
effect on cytokinetic differences between cancer and normal cells. One approach aimed at …
effect on cytokinetic differences between cancer and normal cells. One approach aimed at …