Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook
The discovery of a near-infrared (NIR, 650–900 nm) fluorescent chromophore hemicyanine
dye with high structural tailorability is of great significance in the field of detection …
dye with high structural tailorability is of great significance in the field of detection …
Fluorogenic probes for disease-relevant enzymes
Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …
Small molecule as fluorescent probes for monitoring intracellular enzymatic transformations
All cellular processes are the results of synchronized actions of several intracellular
biochemical pathways. Recent emphasis is to visualize such pathways using appropriate …
biochemical pathways. Recent emphasis is to visualize such pathways using appropriate …
An activatable AIEgen probe for high‐fidelity monitoring of overexpressed tumor enzyme activity and its application to surgical tumor excision
H Li, Q Yao, F Xu, Y Li, D Kim, J Chung… - Angewandte …, 2020 - Wiley Online Library
Monitoring fluctuations in enzyme overexpression facilitates early tumor detection and
excision. An AIEgen probe (DQM‐ALP) for the imaging of alkaline phosphatase (ALP) …
excision. An AIEgen probe (DQM‐ALP) for the imaging of alkaline phosphatase (ALP) …
A comprehensive overview on alkaline phosphatase targeting and reporting assays
Alkaline phosphatase (ALP) is an enzyme that catalyzes the dephosphorylation of various
vital nucleic acids and proteins. A broad range of physiological and pathological processes …
vital nucleic acids and proteins. A broad range of physiological and pathological processes …
Orderly Self‐Assembly of Organic Fluorophores for Sensing and Imaging
Z Li, PZ Liang, TB Ren, L Yuan… - Angewandte Chemie, 2023 - Wiley Online Library
Fluorescence imaging utilizing traditional organic fluorophores is extensively applied in both
cellular and in vivo studies. However, it faces significant obstacles, such as low signal‐to …
cellular and in vivo studies. However, it faces significant obstacles, such as low signal‐to …
Recent progress and prospects of alkaline phosphatase biosensor based on fluorescence strategy
Y Han, J Chen, Z Li, H Chen, H Qiu - Biosensors and Bioelectronics, 2020 - Elsevier
Alkaline phosphatase (ALP) is a membrane-bound enzyme widely present in biological
tissues and is extensively used as a biomarker in clinical diagnosis because abnormal ALP …
tissues and is extensively used as a biomarker in clinical diagnosis because abnormal ALP …
Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging
Fluorogenic probes, small-molecule sensors that unmask brilliant fluorescence upon
exposure to specific stimuli, are powerful tools for chemical biology. Those probes that …
exposure to specific stimuli, are powerful tools for chemical biology. Those probes that …
Enzyme‐mediated in situ self‐assembly promotes in vivo bioorthogonal reaction for pretargeted multimodality imaging
Y Hu, J Zhang, Y Miao, X Wen, J Wang… - Angewandte …, 2021 - Wiley Online Library
Pretargeted imaging has emerged as a promising approach to advance nuclear imaging of
malignant tumors. Herein, we combine the enzyme‐mediated fluorogenic reaction and in …
malignant tumors. Herein, we combine the enzyme‐mediated fluorogenic reaction and in …
Recent advances in bioprobes and biolabels based on cyanine dyes
X Ma, L Shi, B Zhang, L Liu, Y Fu, X Zhang - Analytical and bioanalytical …, 2022 - Springer
As a functional dye, cyanine dye promotes the widespread application of bioprobes in the
fields of medicine, genetics and environment, owing to its advantages of good photophysical …
fields of medicine, genetics and environment, owing to its advantages of good photophysical …