The genetic modification and characterization of T-cells with chimeric antigen receptors
(CARs) allow functionally distinct T-cell subsets to recognize specific tumor cells. The …

Chimeric antigen receptor T-cell (CAR-T) therapy has been prosperous in the treatment of
patients with various types of relapsed/refractory (R/R) B-cell malignancies including diffuse …

Background Cellular therapies could play a role in cancer treatment and regenerative
medicine if it were possible to quickly eliminate the infused cells in case of adverse events …

Adoptive transfer of immune effector cells that are gene modified by retroviral transduction to
express tumor-specific receptors constitutes an attractive approach to treat cancer. In …

Infusions of antigen-specific T cells have yielded therapeutic responses in patients with
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …

Simple Summary Certain immune cells, namely T cells, of cancer patients can be genetically
manipulated to express so-called chimeric antigen receptors (CARs), which enables these …

Adoptive T cell therapy (ACT) is a rapidly evolving therapeutic approach designed to
harness T cell specificity and function to fight diseases. Based on the evidence that T …

Adoptive T-cell therapy can involve donor lymphocyte infusion after allogeneic
hematopoietic stem cell transplantation, the administration of tumor infiltrating lymphocyte …

A major advance in adoptive T‐cell therapy (ACT) is the ability to efficiently endow patient's
T cells with reactivity for tumor antigens through the stable or regulated introduction of genes …

Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial
gene, which allows the conversion of a non-toxic compound into a lethal drug. Although …