COCONUT online: collection of open natural products database
Natural products (NPs) are small molecules produced by living organisms with potential
applications in pharmacology and other industries as many of them are bioactive. This …
applications in pharmacology and other industries as many of them are bioactive. This …
A survey on computational taste predictors
Taste is a sensory modality crucial for nutrition and survival, since it allows the discrimination
between healthy foods and toxic substances thanks to five tastes, ie, sweet, bitter, umami …
between healthy foods and toxic substances thanks to five tastes, ie, sweet, bitter, umami …
Cryptic or silent? The known unknowns, unknown knowns, and unknown unknowns of secondary metabolism
PA Hoskisson, RF Seipke - MBio, 2020 - Am Soc Microbiol
Microbial natural products, particularly those produced by filamentous Actinobacteria,
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …
Classifying natural products from plants, fungi or bacteria using the COCONUT database and machine learning
A Capecchi, JL Reymond - Journal of cheminformatics, 2021 - Springer
Natural products (NPs) represent one of the most important resources for discovering new
drugs. Here we asked whether NP origin can be assigned from their molecular structure in a …
drugs. Here we asked whether NP origin can be assigned from their molecular structure in a …
Comprehensive large-scale integrative analysis of omics data to accelerate specialized metabolite discovery
JJR Louwen, JJJ Van Der Hooft - Msystems, 2021 - Am Soc Microbiol
Microbial specialized metabolites are key mediators in host-microbiome interactions. Most of
the chemical space produced by the microbiome currently remains unexplored and …
the chemical space produced by the microbiome currently remains unexplored and …
Epiphytic and endophytic microbiome of the seagrass Zostera marina: Do they contribute to pathogen reduction in seawater?
D Tasdemir, S Scarpato, C Utermann-Thüsing… - Science of the Total …, 2024 - Elsevier
Seagrass meadows provide crucial ecosystem services for coastal environments and were
shown to reduce the abundance of waterborne pathogens linked to infections in humans …
shown to reduce the abundance of waterborne pathogens linked to infections in humans …
Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes
E Charria-Girón, Y Marin-Felix, U Beutling… - Microbiology …, 2023 - Am Soc Microbiol
Plants of the genus Otoba have been the basis for the treatment of tropical diseases in
indigenous communities of countries like Colombia. Despite the lack of knowledge about …
indigenous communities of countries like Colombia. Despite the lack of knowledge about …
Importance of quorum sensing crosstalk in the brown alga Saccharina latissima epimicrobiome
E Adouane, C Mercier, J Mamelle, E Willocquet… - Iscience, 2024 - cell.com
Brown macroalgae are colonized by diverse microorganisms influencing the physiology of
their host. However, cell-cell interactions within the surface microbiome (epimicrobiome) are …
their host. However, cell-cell interactions within the surface microbiome (epimicrobiome) are …
PIKAChU: a Python-based informatics kit for analysing chemical units
BR Terlouw, SPJM Vromans, MH Medema - Journal of Cheminformatics, 2022 - Springer
As efforts to computationally describe and simulate the biochemical world become more
commonplace, computer programs that are capable of in silico chemistry play an …
commonplace, computer programs that are capable of in silico chemistry play an …
Natural product biosynthetic potential reflects macroevolutionary diversification within a widely distributed bacterial taxon
Flavobacteriaceae spp. are key players in global biogeochemical cycling and are known for
their versatile carbohydrate and peptide catabolism. However, it is currently unknown …
their versatile carbohydrate and peptide catabolism. However, it is currently unknown …