COCONUT online: collection of open natural products database

M Sorokina, P Merseburger, K Rajan, MA Yirik… - Journal of …, 2021 - Springer
Natural products (NPs) are small molecules produced by living organisms with potential
applications in pharmacology and other industries as many of them are bioactive. This …

A survey on computational taste predictors

M Malavolta, L Pallante, B Mavkov, F Stojceski… - … Food Research and …, 2022 - Springer
Taste is a sensory modality crucial for nutrition and survival, since it allows the discrimination
between healthy foods and toxic substances thanks to five tastes, ie, sweet, bitter, umami …

Cryptic or silent? The known unknowns, unknown knowns, and unknown unknowns of secondary metabolism

PA Hoskisson, RF Seipke - MBio, 2020 - Am Soc Microbiol
Microbial natural products, particularly those produced by filamentous Actinobacteria,
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …

Classifying natural products from plants, fungi or bacteria using the COCONUT database and machine learning

A Capecchi, JL Reymond - Journal of cheminformatics, 2021 - Springer
Natural products (NPs) represent one of the most important resources for discovering new
drugs. Here we asked whether NP origin can be assigned from their molecular structure in a …

Comprehensive large-scale integrative analysis of omics data to accelerate specialized metabolite discovery

JJR Louwen, JJJ Van Der Hooft - Msystems, 2021 - Am Soc Microbiol
Microbial specialized metabolites are key mediators in host-microbiome interactions. Most of
the chemical space produced by the microbiome currently remains unexplored and …

Epiphytic and endophytic microbiome of the seagrass Zostera marina: Do they contribute to pathogen reduction in seawater?

D Tasdemir, S Scarpato, C Utermann-Thüsing… - Science of the Total …, 2024 - Elsevier
Seagrass meadows provide crucial ecosystem services for coastal environments and were
shown to reduce the abundance of waterborne pathogens linked to infections in humans …

Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes

E Charria-Girón, Y Marin-Felix, U Beutling… - Microbiology …, 2023 - Am Soc Microbiol
Plants of the genus Otoba have been the basis for the treatment of tropical diseases in
indigenous communities of countries like Colombia. Despite the lack of knowledge about …

Importance of quorum sensing crosstalk in the brown alga Saccharina latissima epimicrobiome

E Adouane, C Mercier, J Mamelle, E Willocquet… - Iscience, 2024 - cell.com
Brown macroalgae are colonized by diverse microorganisms influencing the physiology of
their host. However, cell-cell interactions within the surface microbiome (epimicrobiome) are …

PIKAChU: a Python-based informatics kit for analysing chemical units

BR Terlouw, SPJM Vromans, MH Medema - Journal of Cheminformatics, 2022 - Springer
As efforts to computationally describe and simulate the biochemical world become more
commonplace, computer programs that are capable of in silico chemistry play an …

Natural product biosynthetic potential reflects macroevolutionary diversification within a widely distributed bacterial taxon

SG Silva, M Nabhan Homsi, T Keller-Costa, U Rocha… - Msystems, 2023 - Am Soc Microbiol
Flavobacteriaceae spp. are key players in global biogeochemical cycling and are known for
their versatile carbohydrate and peptide catabolism. However, it is currently unknown …