Obesity is one of the major risk factors for the development of both impaired glucose
tolerance (IGT, or prediabetes) and type 2 diabetes (T2D), and its prevalence worldwide …

Emerging evidence reveals that adipose tissue-associated inflammation is a main
mechanism whereby obesity promotes colorectal cancer risk and progression. Increased …

Abstract The NLRP3-IL-1β pathway plays an important role in adipose tissue (AT)-induced
inflammation and the development of obesity-associated comorbidities. We aimed to …

Background & aims Fibroblast growth factor 19 (FGF19) and 21 (FGF21) have emerged as
key regulators of energy homeostasis. Our aim was to analyze the impact of weight loss …

Context: Obesity acts as a cardiovascular risk factor by mechanisms that are not fully
understood. Osteopontin (OPN) is a proinflammatory mediator involved in tissue remodeling …

OBJECTIVE It has been suggested that individuals with the condition known as
metabolically healthy obesity (MHO) may not have the same increased risk for the …

Nuclear factor E2–related factor 2 (Nrf2) is a transcription factor that functions as a master
regulator of the cellular adaptive response to oxidative stress. Our previous studies showed …

Abstract Lipocalin-2 (LCN2) is a novel adipokine with potential roles in obesity, insulin
resistance, and inflammation. The aim of the present work was to evaluate the effect of …

GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only
known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; …

Reverse transcription quantitative-polymerase chain reaction (RT-qPCR) is a routine
method for gene expression analysis, and reliable results depend on proper normalization …