Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Abstract Objectives Systematic reviews (SRs) of clinical practice guidelines (CPGs) are
unique knowledge syntheses that require tailored approaches to, and greater subjectivity in …

This study aimed to investigate the role of baseline levels of peripheral inflammation when
testing the efficacy of antidepressant augmentation with minocycline in patients with …

Major depressive disorder is a debilitating disease affecting 264 million people worldwide.
While many antidepressant medications are available, few clinical guidelines support …

Decision support systems embodying machine learning models offer the promise of an
improved standard of care for major depressive disorder, but little is known about how …

Exosomal microRNAs (miRNAs) have been suggested to participate in the pathogenesis of
neuropsychiatric diseases, but their role in major depressive disorder (MDD) is unknown …

Background: Successful treatment of major depressive disorder (MDD) can be challenging,
and failures (" treatment-resistant depression"[TRD]) are frequent. Steps to address TRD …

Abstract Treatment-resistant depression (TRD) is a major contributor to the disability caused
by major depressive disorder (MDD). Primary care electronic health records provide an …

The high inter-individual heterogeneity in individuals with depression limits neuroimaging
studies with case-control approaches to identify promising biomarkers for individualized …

Major depression is a devastating disease affecting an increasing number of people from a
young age worldwide, a situation that is expected to be worsened by the COVID-19 …