In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …

Thrombosis remains a major problem in our society, manifesting across multiple
demographic groups and with high associated morbidity and mortality. Thrombus …

Neutrophil extracellular traps (NETs) are complex structures released by activated
neutrophils during inflammatory responses. Due to their unique potential for causing tissue …

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social …

Anticoagulants are the mainstay for the prevention and treatment of thrombosis. However,
bleeding complications remain a primary concern. Recent advances in understanding the …

The interplay between innate immunity and coagulation after infection or injury, termed
immunothrombosis, is the primary cause of disseminated intravascular coagulation (DIC), a …

Background The underlying mechanisms of thrombosis in Lemierre's syndrome and other
septic thrombophlebitis are incompletely understood. Therefore, in this case control study …

Neutrophil extracellular traps contribute to lung injury in cystic fibrosis and asthma, but the
mechanisms are poorly understood. We sought to understand the impact of human NETs on …

Objective In eosinophilic granulomatosis with polyangiitis (EGPA) a prothrombotic state,
including formation of denser fibrin networks with reduced lysability has been observed …

Ischaemic stroke is a major cause of morbidity and mortality worldwide. Blood clotting and
thromboembolism play a central role in the pathogenesis of ischaemic stroke. An increasing …