Over half a century has passed since interferons (IFNs) were discovered and shown to
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …

Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …

Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

Epstein-Barr virus (EBV) causes infectious mononucleosis, triggers multiple sclerosis, and is
associated with 200,000 cancers/year. EBV colonizes the human B cell compartment and …

Epstein-Bar virus (EBV) is widespread within the human population with over 90% of adults
being infected. In response to primary EBV infection, the host mounts an antiviral immune …

Viral infection triggers an early host response through activation of pattern recognition
receptors, including Toll-like receptors (TLR). TLR signaling cascades induce production of …

Epstein‒Barr virus (EBV) is a DNA virus that belongs to the human B lymphotropic
herpesvirus family and is highly prevalent in the human population. Once infected, a host …

Mitochondria respond to many cellular functions and act as central hubs in innate immunity
against viruses. This response is notably due to their role in the activation of interferon (IFN) …

Epstein-Barr virus (EBV) has developed effective strategies to evade host innate immune
responses. Here we reported on mitigation of type I interferon (IFN) production by EBV …

Viral infection initiates a series of signaling cascades that lead to the transcription of
interferons (IFNs), finally inducing interferon-stimulated genes (ISGs) to eliminate viruses …