Interferons and viruses: an evolutionary arms race of molecular interactions
HH Hoffmann, WM Schneider, CM Rice - Trends in immunology, 2015 - cell.com
Over half a century has passed since interferons (IFNs) were discovered and shown to
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …
[HTML][HTML] IRF7: activation, regulation, modification and function
S Ning, JS Pagano, GN Barber - Genes & Immunity, 2011 - nature.com
Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …
Pathogenesis and host control of gammaherpesviruses: lessons from the mouse
E Barton, P Mandal, SH Speck - Annual review of immunology, 2011 - annualreviews.org
Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …
[HTML][HTML] An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
Epstein-Barr virus (EBV) causes infectious mononucleosis, triggers multiple sclerosis, and is
associated with 200,000 cancers/year. EBV colonizes the human B cell compartment and …
associated with 200,000 cancers/year. EBV colonizes the human B cell compartment and …
Immune evasion by Epstein-Barr virus
ME Ressing, M van Gent, AM Gram… - Epstein Barr Virus …, 2015 - Springer
Epstein-Bar virus (EBV) is widespread within the human population with over 90% of adults
being infected. In response to primary EBV infection, the host mounts an antiviral immune …
being infected. In response to primary EBV infection, the host mounts an antiviral immune …
[HTML][HTML] Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling
M van Gent, SGE Braem, A de Jong, N Delagic… - PLoS …, 2014 - journals.plos.org
Viral infection triggers an early host response through activation of pattern recognition
receptors, including Toll-like receptors (TLR). TLR signaling cascades induce production of …
receptors, including Toll-like receptors (TLR). TLR signaling cascades induce production of …
[HTML][HTML] Epstein-Barr virus infection: the micro and macro worlds
W Huang, L Bai, H Tang - Virology Journal, 2023 - Springer
Epstein‒Barr virus (EBV) is a DNA virus that belongs to the human B lymphotropic
herpesvirus family and is highly prevalent in the human population. Once infected, a host …
herpesvirus family and is highly prevalent in the human population. Once infected, a host …
BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction
G Vilmen, D Glon, G Siracusano, M Lussignol, Z Shao… - Autophagy, 2021 - Taylor & Francis
Mitochondria respond to many cellular functions and act as central hubs in innate immunity
against viruses. This response is notably due to their role in the activation of interferon (IFN) …
against viruses. This response is notably due to their role in the activation of interferon (IFN) …
[HTML][HTML] Suppression of cGAS-and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1
WY Lui, A Bharti, NHM Wong, S Jangra… - PLoS …, 2023 - journals.plos.org
Epstein-Barr virus (EBV) has developed effective strategies to evade host innate immune
responses. Here we reported on mitigation of type I interferon (IFN) production by EBV …
responses. Here we reported on mitigation of type I interferon (IFN) production by EBV …
Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production
Viral infection initiates a series of signaling cascades that lead to the transcription of
interferons (IFNs), finally inducing interferon-stimulated genes (ISGs) to eliminate viruses …
interferons (IFNs), finally inducing interferon-stimulated genes (ISGs) to eliminate viruses …