The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds
Allergies to peanuts, tree nuts, and sesame seeds are among the most important food-
related causes of anaphylaxis. Important clinical questions include: Why is there a variable …
related causes of anaphylaxis. Important clinical questions include: Why is there a variable …
Regional and temporal coordinated mutation patterns in SARS-CoV-2 spike protein revealed by a clustering and network analysis
SARS-CoV-2 has steadily mutated during its spread to> 300 million people throughout the
world. The WHO has designated strains with certain mutations,“variants of concern”(VOC) …
world. The WHO has designated strains with certain mutations,“variants of concern”(VOC) …
CrossDome: an interactive R package to predict cross-reactivity risk using immunopeptidomics databases
AF Fonseca, DA Antunes - Frontiers in Immunology, 2023 - frontiersin.org
T-cell-based immunotherapies hold tremendous potential in the fight against cancer, thanks
to their capacity to specifically targeting diseased cells. Nevertheless, this potential has been …
to their capacity to specifically targeting diseased cells. Nevertheless, this potential has been …
Still SDAPing along: 20 years of the structural database of allergenic proteins
The introduction of plant extracts to mitigate the symptoms of “hay fever”, about a century
ago, led to discoveries beginning sixty years ago on determining the sequences and …
ago, led to discoveries beginning sixty years ago on determining the sequences and …
[HTML][HTML] The updated Structural Database of Allergenic Proteins (SDAP 2.0) provides 3D models for allergens and incorporated bioinformatics tools
Background Allergenic proteins can cause IgE-mediated adverse reactions in sensitized
individuals. Although the sequences of many allergenic proteins have been identified …
individuals. Although the sequences of many allergenic proteins have been identified …
PCP consensus protein/peptide alphavirus antigens stimulate broad spectrum neutralizing antibodies
CH Schein, G Rafael, WS Baker, ES Anaya… - Peptides, 2022 - Elsevier
Vaccines based on proteins and peptides may be safer and if calculated based on many
sequences, more broad-spectrum than those designed based on single strains …
sequences, more broad-spectrum than those designed based on single strains …
Identifying Similar Allergens and Potentially Cross-Reacting Areas Using Structural Database of Allergenic Proteins (SDAP) Tools and D-Graph
CH Schein - Food Allergens: Methods and Protocols, 2023 - Springer
Abstract The Structural Database of Allergenic Proteins (SDAP) provides rapid search tools
to identify similarities among allergens, their IgE epitopes, and to determine the potential …
to identify similarities among allergens, their IgE epitopes, and to determine the potential …
Displaying alphavirus physicochemical consensus antigens on immunogenic liposomes enhances antibody elicitation in mice
Cobalt-porphyrin phospholipid displays recombinant protein antigens on liposome surfaces
via antigen polyhistidine-tag (His-tag), and when combined with monophosphorylated lipid …
via antigen polyhistidine-tag (His-tag), and when combined with monophosphorylated lipid …
[HTML][HTML] Beyond mutations: Accounting for quantitative changes in the analysis of protein evolution
Molecular phylogenetic research has relied on the analysis of the coding sequences by
genes or of the amino acid sequences by the encoded proteins. Enumerating the numbers …
genes or of the amino acid sequences by the encoded proteins. Enumerating the numbers …
Producing physicochemical property consensus alphavirus protein antigens for broad spectrum vaccine design
There is a pressing need for new vaccines against alphaviruses, which can cause fatal
encephalitis (Venezuelan equine encephalitis virus (VEEV) and others) and severe …
encephalitis (Venezuelan equine encephalitis virus (VEEV) and others) and severe …