It has long been hypothesized that conditioning mechanisms play major roles in addiction.
Specifically, the associations between rewarding properties of drugs of abuse and the drug …

Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

The current study examined whether adolescent rats are more vulnerable than adult rats to
the lasting adverse effects of cannabinoid exposure on brain and behavior. Male Wistar rats …

Drugs of abuse dynamically regulate adult neurogenesis, which appears important for some
types of learning and memory. Interestingly, a major site of adult neurogenesis, the …

Drug addiction is a chronic relapsing disorder, and a significant amount of research has
been devoted to understand the factors that contribute to the development, loss of control …

Cocaine addiction is a chronic brain disease in which the drug seeking habits and profound
cognitive, emotional and motivational alterations emerge from drug-induced …

BACKGROUND: The perseverance of the motivational salience of drug-associated
memories is an obstacle to the successful treatment of drug addiction and is often a …

The hippocampus is believed to play a role in processing information relative to the context
in which emotionally salient experiences occur but evidence on the specific contribution of …

Rationale The post-extinction exposure of rats to a sub-conditioning procedure (SCP; ie,
retraining with a shock intensity that is too weak to induce by itself significant fear …

Addictive drugs induce a dopamine signal that contributes to the initiation of addiction, and
the dopamine signal influences drug-associated memories that perpetuate drug use. The …