Introduction: Parkinson's disease (PD) is characterized by fibrillation of disordered proteins
known as Lewy bodies in the substantia nigra that also undergo progressive …

Parkinson's disease (PD) is the second most common neurodegenerative diseases with no
cure yet and its major hallmark is α-synuclein fibrillary aggregates. The crucial role of α …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the
accumulation of α-synuclein (α-Syn) aggregates. However, there are currently no effective …

The role of the blood-brain barrier (BBB) is to control trafficking of biomolecules and protect
the brain. This function can be compromised by pathological conditions. Parkinson's disease …

Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of
misfolded α-synuclein fibrils, leading to the formation of Lewy bodies. Currently, no effective …

Amyloid aggregation of α-synuclein (αSN) protein amplifies the pathogenesis of
neurodegenerative diseases (NDs) such as Parkinson's disease (PD). Consequently …

The pathogenesis of Parkinson's disease (PD) is closely linked to the massive presence of
Lewy vesicles and Lewy axons in the cytoplasm of neurons, mainly consisting of α-synuclein …

This article reveals the binding mechanism between glycyrrhizic acid (GA) and α-synuclein
to may provide further information for the modulation of synucleinopathies using bioactive …

Guided by in silico analysis tools and biotransformation technology, new derivatives of
natural compounds with heightened bioactivities can be explored and synthesized …