Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …

Post‐translational modifications (PTMs) of proteins not only exponentially increase the
diversity of proteoforms, but also contribute to dynamically modulating the localization …

Conspectus Protein post-translational modification (PTM) is a major mechanism for
functional diversification of the human genome and plays a crucial role in almost every …

Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Protein lipidation dramatically affects protein structure, localization, and trafficking via
remodeling protein–membrane and protein–protein interactions through hydrophobic lipid …

Metabolic reprogramming is an essential hallmark of tumors, and metabolic abnormalities
are strongly associated with the malignant phenotype of tumor cells. This is closely related to …

Latent bioreactive unnatural amino acids (Uaas) have been widely used in the development
of covalent drugs and identification of protein interactors, such as proteins, DNA, RNA and …

Protein‐protein interactions (PPIs) play critical roles in almost all cellular signal transduction
events. Characterization of PPIs without interfering with the functions of intact cells is very …

The ability to genetically encode noncanonical amino acids (ncAAs) has empowered
proteins with improved or previously unknown properties. However, existing strategies in …

Arginine and lysine, frequently appearing as a pair on histones, have been proven to carry
diverse modifications and execute various epigenetic regulatory functions. However, the …