Hypoxia is a condition always present in tumor environment owing to the fast growth of
tumor cells not supported by adequate blood supply. There is increasing evidence that …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

This review explores the concept of using privileged scaffolds to identify biologically active
compounds through building chemical libraries. We hope to accomplish three main …

Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signalling
pathways are affording demonstrable therapeutic efficacy in mouse models of cancer and in …

Abstract Hypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral
role in the body's response to low oxygen concentrations, or hypoxia. HIF-1 is among the …

From approximately the early 1980s, the “influence of natural products” upon drug discovery
in all therapeutic areas apparently has been on the wane because of the advent of …

Glioblastomas, like other solid tumors, have extensive areas of hypoxia and necrosis. The
importance of hypoxia in driving tumor growth is receiving increased attention. Hypoxia …

The identification of small molecules that inhibit the sequence-specific binding of
transcription factors to DNA is an attractive approach for regulation of gene expression …

Immune cells are often exposed to low oxygen tensions, which markedly affect cellular
metabolism. We describe how activated T cells adapt to the changing energy supplies in …

It is widely recognized that the vasculature of the tumor is inadequate to meet the demands
of the growing mass. The malformed vasculature is at least in part responsible for regions of …