Medicine today faces the combined challenge of an increasing number of untreatable
diseases and fewer drugs reaching the clinic. While pharmaceutical companies have …

Advancements in the field of tissue engineering have led to the elucidation of physical and
chemical characteristics of physiological basement membranes (BM) as specialized forms of …

Chimeric antigen receptor (CAR) T cells have transformed the treatment landscape for
hematological malignancies. However, CAR T cells are less efficient against solid tumors …

High throughput drug screening is an established approach to investigate tumor biology and
identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not …

Measuring single cell responses to the universe of chemicals (drugs, natural products,
environmental toxicants etc.) is of paramount importance to human health as phenotypic …

Abstract/outline The field of high content imaging has steadily evolved and expanded
substantially across many industry and academic research institutions since it was first …

Background Cyclin-dependent kinase 9 (CDK9) stimulates oncogenic transcriptional
pathways in cancer and CDK9 inhibitors have emerged as promising therapeutic …

Organoids are units of function of a given organ able to reproduce, in culture, a biological
structure similar in architecture and function to its counterpart in vivo. Today, it is possible to …

Tumor organoids have been pushed forward as advanced model systems for in vitro
oncology drug testing, with the eventual goal to direct personalized cancer treatments …

An accumulation of previous work has established organoids as good preclinical models of
human tumors, facilitating translation from basic research to clinical practice. They are …