Antioxidant response element (ARE)-mediated expression and coordinated induction of
genes encoding detoxifying enzymes is one mechanism of critical importance to cellular …

γ-Glutamylcysteine synthetase (γ-GCS) is a rate-limiting enzyme in the de novo synthesis of
glutathione, a known scavenger of electrophiles and reactive oxygen species (ROS). The γ …

Abstract NRH: quinone oxidoreductase 2 (QR2) is a cytosolic enzyme that catalyzes the
reduction of quinones, such as menadione and co-enzymes Q. With the aim of …

Quinones are highly reactive molecules that readily undergo either one-or two-electron
reduction. One-electron reduction of quinones or their derivatives by enzymes such as …

NRH: quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that utilizes NRH as
electron donor. The present studies investigate the role of NQO2 in metabolic detoxification …

We conducted a hospital-based case-control study of 814 lung cancer patients and 1123
controls to examine the association of the NAD (P) H: quinone oxidoreductase 1 (NQO1) …

Among the numerous co-adjuvant therapies, which could influence the incidence and
progression of diabetic complications, flavonoids, naturally occurring antioxidants, are …

Xenobiotics and antioxidants induce expression of detoxifying enzymes including NAD (P)
H: quinone oxidoreductase (NQO1), NRH: quinone oxidoreductase (NQO2), and glutathione …

Publisher Summary This chapter discusses the role of NF-E2 related factors in oxidative
stress. Reactive oxygen species (ROS) cause oxidative stress and have a profound impact …

Background and Objectives: The clinical use of doxorubicin, one of the most effective
antitumor agents, soon proved to be hampered by such serious problems as the …