The use of alternative strategies for enhanced nanoparticle delivery to solid tumors

M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

MicroRNA delivery through nanoparticles

SWL Lee, C Paoletti, M Campisi, T Osaki… - Journal of Controlled …, 2019 - Elsevier
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …

Form follows function: nanoparticle shape and its implications for nanomedicine

C Kinnear, TL Moore, L Rodriguez-Lorenzo… - Chemical …, 2017 - ACS Publications
This review is a comprehensive description of the past decade of research into
understanding how the geometry and size of nanoparticles affect their interaction with …

[HTML][HTML] Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment

J Park, Y Choi, H Chang, W Um, JH Ryu, IC Kwon - Theranostics, 2019 - ncbi.nlm.nih.gov
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

[HTML][HTML] Nanocarrier-based drug combination therapy for glioblastoma

M Zhao, D van Straten, MLD Broekman, V Préat… - Theranostics, 2020 - ncbi.nlm.nih.gov
The current achievements in treating glioblastoma (GBM) patients are not sufficient because
many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem …

An overview of carboxymethyl derivatives of chitosan: Their use as biomaterials and drug delivery systems

B Fonseca-Santos, M Chorilli - Materials Science and Engineering: C, 2017 - Elsevier
Chitin is one of the most abundant natural polymers in the world and is used for the
production of chitosan by deacetylation. Chitosan is nontoxic and biodegradable and …

Targeting tumor-associated fibroblasts for therapeutic delivery in desmoplastic tumors

L Miao, Q Liu, CM Lin, C Luo, Y Wang, L Liu, W Yin… - Cancer research, 2017 - AACR
The off-target distribution of anticancer nanoparticles to fibroblasts creates a barrier to the
effective treatment of desmoplastic tumors. However, we hypothesized that this nanoparticle …

Modulating the tumor microenvironment to enhance tumor nanomedicine delivery

B Zhang, Y Hu, Z Pang - Frontiers in pharmacology, 2017 - frontiersin.org
Nanomedicines including liposomes, micelles, and nanoparticles based on the enhanced
permeability and retention (EPR) effect have become the mainstream for tumor treatment …

Targeted therapy of breast tumor by PLGA-based nanostructures: The versatile function in doxorubicin delivery

TS Dongsar, TT Dongsar, N Molugulu… - Environmental …, 2023 - Elsevier
Breast carcinoma is a molecularly diverse illness, and it is among the most prominent and
often reported malignancies in female across the globe. Surgical intervention …

A nanomedicine structure–activity framework for research, development, and regulation of future cancer therapies

B Youden, R Jiang, AJ Carrier, MR Servos, X Zhang - ACS nano, 2022 - ACS Publications
Despite their clinical success in drug delivery applications, the potential of theranostic
nanomedicines is hampered by mechanistic uncertainty and a lack of science-informed …