GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …

Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and
disability in infants and children. Although several preclinical models using rodents of …

Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …

Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …

Ionic currents and the network-driven patterns they generate differ in immature and adult
neurons: The developing brain is not a “small adult brain.” One of the most investigated …

γ-Aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, early in
postnatal life exerts a depolarizing and excitatory action. This depends on accumulation of …

GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

Developing networks follow common rules to shift from silent cells to coactive networks that
operate via thousands of synapses. This review deals with some of these rules and in …

The developing brain is talkative but its language is not that of the adult. Most if not all
voltage and transmitter-gated ionic currents follow a developmental sequence and network …