Targeting MDMX for cancer therapy: rationale, strategies, and challenges
DH Yu, ZY Xu, S Mo, L Yuan, XD Cheng… - Frontiers in …, 2020 - frontiersin.org
The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor
suppressor p53 and has been implicated in the initiation and progression of human cancers …
suppressor p53 and has been implicated in the initiation and progression of human cancers …
The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation
H Wang, B Li, K Asha, RL Pangilinan… - Journal of Biological …, 2021 - ASBMB
Zinc deficiency has been linked to human diseases, including cancer. MDMX, a crucial zinc-
containing negative regulator of p53, has been found to be amplified or overexpressed in …
containing negative regulator of p53, has been found to be amplified or overexpressed in …
MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment
B Wang, CB Lim, J Yan, L Li, J Wang… - Journal of Molecular …, 2020 - academic.oup.com
A role of tumor-suppressive activity of p53 in the tumor microenvironment (TME) has been
implicated but remains fairly understudied. To address this knowledge gap, we leveraged …
implicated but remains fairly understudied. To address this knowledge gap, we leveraged …
Understanding the interaction of 14‐3‐3 proteins with hDMX and hDM2: a structural and biophysical study
p53 plays a critical role in regulating diverse biological processes: DNA repair, cell cycle
arrest, apoptosis and senescence. The p53 pathway has therefore served as the focus of …
arrest, apoptosis and senescence. The p53 pathway has therefore served as the focus of …