Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

Brain ischemia and reperfusion (I/R) is one of the most severe clinical manifestations of
ischemic stroke, placing a significant burden on both individuals and society. The only FDA …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse
neuro-immune diseases, and may aggravate the course of several neuropsychiatric …

This analytical review summarizes literature data and our own research on HSP70-
dependent mechanisms of neuroprotection and discusses potential pharmacological agents …

Nitric oxide (NO) is an important gasotransmitter molecule that is involved in numerous
physiological processes throughout the nervous system. In addition to its involvement in …

Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-
reperfusion injury. RNS activate multiple signaling pathways and participate in different …

Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke
treatment, but its clinical use is limited due to the narrow therapeutic time window and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, and it is currently the
seventh leading cause of death worldwide. It is characterized by the extracellular …

Methods: Rats were subjected to 3 h or 90 min of middle cerebral artery occlusion (MCAO)
and randomized to intraperitoneal C21 (0.03 mg/kg) or saline at reperfusion. Animals were …