Monocytes, macrophages, and metabolic disease in atherosclerosis

MC Flynn, G Pernes, MKS Lee… - Frontiers in …, 2019 - frontiersin.org
Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease,
in which macrophages are responsible for taking up these lipids and driving disease …

Myeloid-derived suppressor cells: ductile targets in disease

FM Consonni, C Porta, A Marino, C Pandolfo… - Frontiers in …, 2019 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of
immature myeloid cells with major regulatory functions and rise during pathological …

Translation of cell therapies to treat autoimmune disorders

JM Mehta, SC Hiremath, C Chilimba, A Ghasemi… - Advanced Drug Delivery …, 2023 - Elsevier
Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …

Myeloid-derived suppressor cells (MDSC): When good intentions go awry

MD Sanchez-Pino, MJ Dean, AC Ochoa - Cellular immunology, 2021 - Elsevier
MDSC are a heterogeneous population of immature myeloid cells that are released by
biological stress such as tissue damage and inflammation. Conventionally, MDSC are …

Mitochondrial DNA activates the NLRP3 inflammasome and predisposes to type 1 diabetes in murine model

D Carlos, FRC Costa, CA Pereira, FA Rocha… - Frontiers in …, 2017 - frontiersin.org
Although a correlation between polymorphisms of NOD-like receptor family-pyrin domain
containing 3 (NLRP3) and predisposition to type 1 diabetes (T1D) has been identified, the …

Emerging roles of myeloid-derived suppressor cells in diabetes

S Wang, Q Tan, Y Hou, H Dou - Frontiers in Pharmacology, 2021 - frontiersin.org
Diabetes is a syndrome characterized by hyperglycemia with or without insulin resistance.
Its etiology is attributed to the combined action of genes, environment and immune cells …

MDSCs, ageing and inflammageing

G Pawelec, E Picard, V Bueno, CP Verschoor… - Cellular …, 2021 - Elsevier
The challenge of distinguishing between changes attributable to ageing and those
attributable to pathology is even greater for the immune system than for many other organs …

Myeloid derived suppressor cells and autoimmunity

P Boros, J Ochando, M Zeher - Human immunology, 2016 - Elsevier
Myeloid-derived suppressor cells are a heterogeneous group of immature myeloid cells with
immunoregulatory function. When activated and expanded, these cells can suppress T cell …

Myeloid‐derived suppressor cells in the therapy of autoimmune diseases

M Bekić, S Tomić - European Journal of Immunology, 2023 - Wiley Online Library
Myeloid‐derived suppressor cells (MDSCs) are well recognized as critical factors in the
pathology of tumors. However, their roles in autoimmune diseases are still unclear, which …

[HTML][HTML] MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance

SI Blum, JP Taylor, JM Barra, AR Burg, Q Shang… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Type 1 diabetes (T1D) is an autoimmune disease resulting in pancreatic β cell
destruction. Coxsackievirus B3 (CVB3) infection and melanoma differentiation-associated …