Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …

Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …

Background The microbiota–gut–brain axis plays an important role in the development of
depression. The aim of this study was to investigate the effects of 5-HT on cognitive function …

The use of SSRIs for the treatment of depression and anxiety in young people is increasing.
However, the effects of SSRIs in adolescence, a time when there are substantial changes in …

Quercetin is a polyphenol with multiple biological activities, and results of our preliminary
study showed that it could shorten the immobility time of mice in the forced swimming test …

Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …

Women are twice as likely as men to experience emotional dysregulation after stress,
resulting in substantially higher psychopathology for equivalent lifetime stress exposure, yet …

Depression is a complex psychiatric disorder. Previous studies have shown that running
exercise reverses depression-like behavior faster and more effectively than fluoxetine …

As an adverse form of early-life stress (ELS), maternal separation (MS) can interfere with the
development of cognition and behaviors of adolescent rodents. Brain-derived neurotrophic …

Aims Fluoxetine (FLX) is a common selective serotonin reuptake inhibitor, which is used in
adolescents with psychiatric disorders. Controversial results have been obtained in different …