SERS nanoparticles in medicine: from label-free detection to spectroscopic tagging

LA Lane, X Qian, S Nie - Chemical reviews, 2015 - ACS Publications
The development of diagnostic and therapeutic nanoparticles for biomedical applications is
of broad current interest in science, engineering, and medicine. The fundamental basis is …

[HTML][HTML] Metabolic pathways regulating colorectal cancer initiation and progression

S La Vecchia, C Sebastián - Seminars in cell & developmental biology, 2020 - Elsevier
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Despite
recent advances in the molecular genetics of CRC, poor treatment outcomes highlight the …

Chemometric methods in data processing of mass spectrometry-based metabolomics: A review

L Yi, N Dong, Y Yun, B Deng, D Ren, S Liu… - Analytica chimica acta, 2016 - Elsevier
This review focuses on recent and potential advances in chemometric methods in relation to
data processing in metabolomics, especially for data generated from mass spectrometric …

Metabolic phenotyping in clinical and surgical environments

JK Nicholson, E Holmes, JM Kinross, AW Darzi… - Nature, 2012 - nature.com
Metabolic phenotyping involves the comprehensive analysis of biological fluids or tissue
samples. This analysis allows biochemical classification of a person's physiological or …

Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation

D Zhang, Y Wang, Z Shi, J Liu, P Sun, X Hou, J Zhang… - Cell reports, 2015 - cell.com
Cancer-associated fibroblasts (CAFs) provide critical metabolites for tumor growth and
undergo metabolic reprogramming to support glycolysis. However, the molecular …

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

MJ Piao, KA Kang, IK Lee, HS Kim, S Kim, JY Choi… - Toxicology letters, 2011 - Elsevier
Silver nanoparticles (AgNPs), which have well-known antimicrobial properties, are
extensively used in various medical and general applications. Despite the widespread use …

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry

A Hirayama, K Kami, M Sugimoto, M Sugawara, N Toki… - Cancer research, 2009 - AACR
Most cancer cells predominantly produce energy by glycolysis rather than oxidative
phosphorylation via the tricarboxylic acid (TCA) cycle, even in the presence of an adequate …

Translational metabolomics: current challenges and future opportunities

FR Pinu, SA Goldansaz, J Jaine - Metabolites, 2019 - mdpi.com
Metabolomics is one of the latest omics technologies that has been applied successfully in
many areas of life sciences. Despite being relatively new, a plethora of publications over the …

Metabolomics in cancer biomarker discovery: current trends and future perspectives

EG Armitage, C Barbas - Journal of pharmaceutical and biomedical …, 2014 - Elsevier
Cancer is one of the most devastating human diseases that causes a vast number of
mortalities worldwide each year. Cancer research is one of the largest fields in the life …

Chemometrics in metabolomics—a review in human disease diagnosis

R Madsen, T Lundstedt, J Trygg - Analytica chimica acta, 2010 - Elsevier
Metabolomics is a post genomic research field concerned with developing methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …