The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this
pathway represent the main treatment modality. Endocrine therapy has proven successful in …

Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the
worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I …

Simple Summary Poly-and perfluoroalkylated substances (PFAS) are industrial chemicals
found in many household products that persist in the environment. While several excellent …

Despite the numerous investigations on resistance mechanisms, drug resistance in cancer
therapies still limits favorable outcomes in cancer patients. The complexities of the inherent …

Simple Summary Triple-negative breast cancer (TNBC) outcomes are improving since the
implementation of immunotherapy. However, objective response rates are still limited to a …

Simple Summary Breast cancer comprises a wide variety of cancer cells that present distinct
phenotypes and develop various nutrient dependencies to grow and survive in stressful …

The human genome is composed of unique DNA sequences that encode proteins and
unique sequence noncoding RNAs that are essential for normal development and cellular …

The human genome is partitioned into a collection of genomic features, inclusive of genes,
transposable elements, lamina interacting regions, early replicating control elements and cis …

Background Aberrant epigenetic remodeling events contribute to progression and
metastasis of breast cancer (Bca). The specific mechanims that epigenetic factors rely on to …