Risk factors for lung cancer worldwide
Lung cancer is the most frequent malignant neoplasm in most countries, and the main
cancer-related cause of mortality worldwide in both sexes combined. The geographic and …
cancer-related cause of mortality worldwide in both sexes combined. The geographic and …
Tobacco-related carcinogenesis in head and neck cancer
AR Jethwa, SS Khariwala - Cancer and Metastasis Reviews, 2017 - Springer
Head and neck cancer (head and neck squamous cell carcinoma (HNSCC)) is a devastating
disease. Patients require intensive treatment that is often disfiguring and debilitating. Those …
disease. Patients require intensive treatment that is often disfiguring and debilitating. Those …
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
Non-small-cell lung cancer
In the decade since the last Lancet Seminar on lung cancer there have been advances in
many aspects of the classification, diagnosis, and treatment of non-small-cell lung cancer …
many aspects of the classification, diagnosis, and treatment of non-small-cell lung cancer …
Lung carcinogenesis by tobacco smoke
SS Hecht - International journal of cancer, 2012 - Wiley Online Library
Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …
Tobacco smoke carcinogens and lung cancer
SS Hecht - Journal of the national cancer institute, 1999 - academic.oup.com
The complexity of tobacco smoke leads to some confusion about the mechanisms by which
it causes lung cancer. Among the multiple components of tobacco smoke, 20 carcinogens …
it causes lung cancer. Among the multiple components of tobacco smoke, 20 carcinogens …
Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
Biomarkers of exposure to secondhand and thirdhand tobacco smoke: recent advances and future perspectives
S Torres, C Merino, B Paton, X Correig… - International journal of …, 2018 - mdpi.com
Smoking is the leading preventable disease worldwide and passive smoking is estimated to
be the cause of about 1.0% of worldwide mortality. The determination of tobacco smoke …
be the cause of about 1.0% of worldwide mortality. The determination of tobacco smoke …
Cigarette filter ventilation and its relationship to increasing rates of lung adenocarcinoma
Abstract The 2014 Surgeon General's Report on smoking and health concluded that
changing cigarette designs have caused an increase in lung adenocarcinomas, implicating …
changing cigarette designs have caused an increase in lung adenocarcinomas, implicating …
Exposure and metabolic activation biomarkers of carcinogenic tobacco-specific nitrosamines
SS Hecht, I Stepanov, SG Carmella - Accounts of chemical …, 2016 - ACS Publications
Conspectus Lung cancer is the leading cause of cancer death in the world, and cigarette
smoking is its main cause. Oral cavity cancer is another debilitating and often fatal cancer …
smoking is its main cause. Oral cavity cancer is another debilitating and often fatal cancer …