Targeting poly (ADP-ribose) polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation
The highly conserved abundant nuclear protein poly (ADP-ribose) polymerase1 (PARP1)
functions at the center of cellular stress response and is mainly implied in DNA damage …
functions at the center of cellular stress response and is mainly implied in DNA damage …
[HTML][HTML] Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts
EJ Brettrager, RCAM van Waardenburg - Cancer Drug Resistance, 2019 - ncbi.nlm.nih.gov
Our genomic DNA is under constant assault from endogenous and exogenous sources,
which needs to be resolved to maintain cellular homeostasis. The eukaryotic DNA repair …
which needs to be resolved to maintain cellular homeostasis. The eukaryotic DNA repair …
Poly (ADP-ribose)—a unique natural polymer structural features, biological role and approaches to the chemical synthesis
MS Drenichev, SN Mikhailov - Nucleosides, Nucleotides and …, 2015 - Taylor & Francis
Poly (ADP-ribose)(PAR) is a natural polymer, taking part in numerous important cellular
processes. Several enzymes are involved in biosynthesis and degradation of PAR. One of …
processes. Several enzymes are involved in biosynthesis and degradation of PAR. One of …
The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo
IA Chernyshova, AL Zakharenko, NN Kurochkin… - Molecules, 2022 - mdpi.com
The use of cancer chemotherapy sensitizers is a promising approach to induce the effect of
clinically used anticancer treatments. One of the interesting targets is Tyrosyl-DNA …
clinically used anticancer treatments. One of the interesting targets is Tyrosyl-DNA …
Crosslinking of chitosan with dialdehyde derivatives of nucleosides and nucleotides. Mechanism and comparison with glutaraldehyde
SN Mikhailov, AN Zakharova… - … and nucleic acids, 2016 - Taylor & Francis
In medical and pharmaceutical applications, chitosan is used as a component of hydrogels–
macromolecular networks swollen in water. Chemical hydrogels are formed by covalent …
macromolecular networks swollen in water. Chemical hydrogels are formed by covalent …
Bioinformatic analysis of the nicotinamide binding site in poly (ADP-ribose) polymerase family proteins
G Manasaryan, D Suplatov, S Pushkarev, V Drobot… - Cancers, 2021 - mdpi.com
Simple Summary The PARP family consists of 17 proteins, and some of them are
responsible for cancer cells' viability. Much attention is therefore given to the search for …
responsible for cancer cells' viability. Much attention is therefore given to the search for …
Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy
AO Komarova, MS Drenichev… - Journal of enzyme …, 2018 - Taylor & Francis
A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors based on disaccharide
nucleosides was identified. TDP1 plays an essential role in the resistance of cancer cells to …
nucleosides was identified. TDP1 plays an essential role in the resistance of cancer cells to …
[HTML][HTML] Aminomethylmorpholino Nucleosides as Novel Inhibitors of PARP1 and PARP2: Experimental and Molecular Modeling Analyses of Their Selectivity and …
I Chernyshova, I Vasil'eva, N Moor… - International Journal of …, 2024 - mdpi.com
Poly (ADP-ribose) polymerases 1 and 2 (PARP1 and PARP2) play a key role in DNA repair.
As major sensors of DNA damage, they are activated to produce poly (ADP-ribose) …
As major sensors of DNA damage, they are activated to produce poly (ADP-ribose) …
Cytomegalovirus in plasma of acute coronary syndrome patients
EA Nikitskaya, JC Grivel, EV Maryukhnich… - Acta Naturae …, 2016 - cyberleninka.ru
The relationship between acute coronary syndrome (ACS) and local and systemic
inflammation, including accumulation of macrophages in atherosclerotic plaques and …
inflammation, including accumulation of macrophages in atherosclerotic plaques and …
Design, synthesis and molecular modeling study of conjugates of ADP and morpholino nucleosides as a novel class of inhibitors of PARP-1, PARP-2 and PARP-3
YV Sherstyuk, NV Ivanisenko, AL Zakharenko… - International Journal of …, 2019 - mdpi.com
We report on the design, synthesis and molecular modeling study of conjugates of
adenosine diphosphate (ADP) and morpholino nucleosides as potential selective inhibitors …
adenosine diphosphate (ADP) and morpholino nucleosides as potential selective inhibitors …