Pirfenidone (PFN) is an anti-fibrotic drug with significant anti-inflammatory property used for
treatment of fibrotic conditions such as idiopathic pulmonary fibrosis (IPF). In the coronavirus …

Pirfenidone, initially indicated for lung fibrosis, has gone beyond its original purpose, and
shown promise in eye care. This detailed review tracks its evolution from lung treatment to …

Cardiac fibrosis is one of the main causes of heart failure, significantly contributing to
mortality. The discovery and development of effective therapies able to heal fibrotic …

The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of
widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue …

Idiopathic pulmonary fibrosis (IPF) is a chronic inflammatory and fibrotic response-driven
lung disease that is difficult to cure because it manifests excessive profibrotic cytokines (eg …

Objective: This study was conducted to establish a rat model of acute exacerbation of
idiopathic pulmonary fibrosis (AE-IPF) using the combination of bleomycin (BLM) and …

In systemic sclerosis (SSc), abnormalities in microvessel morphology occur early and evolve
into a distinctive vasculopathy that relentlessly advances in parallel with the development of …

Pulmonary fibrosis (PF) is a progressive and chronic lung disease characterized by
excessive extracellular matrix (ECM) deposition and fibroblast proliferation. Endothelial-to …

Mechanical forces provide critical biological signals to cells during healthy and aberrant
organ development as well as during disease processes in adults. Within the …

Implantable electrodes have been utilized for decades to stimulate, sense, or monitor a
broad range of biological processes, with examples ranging from glucose monitoring …