Cannabinoids and the gut: new developments and emerging concepts
AA Izzo, KA Sharkey - Pharmacology & therapeutics, 2010 - Elsevier
Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …
Endocannabinoids in the Gut
NV DiPatrizio - Cannabis and cannabinoid research, 2016 - liebertpub.com
Cannabis has been used medicinally for centuries to treat a variety of disorders, including
those associated with the gastrointestinal tract. The discovery of our bodies' own “cannabis …
those associated with the gastrointestinal tract. The discovery of our bodies' own “cannabis …
Inhibitory effect of cannabichromene, a major non‐psychotropic cannabinoid extracted from Cannabis sativa, on inflammation‐induced hypermotility in mice
BACKGROUND AND PURPOSE Cannabichromene (CBC) is a major non‐psychotropic
phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient …
phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient …
Linking mitochondria and synaptic transmission: the CB1 receptor
MA Djeungoue‐Petga, E Hebert‐Chatelain - Bioessays, 2017 - Wiley Online Library
CB1 receptors are functionally present within brain mitochondria (mtCB1), although they are
usually considered specifically targeted to plasma membrane. Acute activation of mtCB1 …
usually considered specifically targeted to plasma membrane. Acute activation of mtCB1 …
The role of purinergic pathways in the pathophysiology of gut diseases: pharmacological modulation and potential therapeutic applications
Gut homeostasis results from complex neuro-immune interactions aimed at triggering
stereotypical and specific programs of coordinated mucosal secretion and powerful motor …
stereotypical and specific programs of coordinated mucosal secretion and powerful motor …
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1‐independent effects
BACKGROUND AND PURPOSE Allyl isothiocyanate (AITC, mustard oil), a constituent of
many common cruciferous vegetables (Brassicaceae), activates transient receptor potential …
many common cruciferous vegetables (Brassicaceae), activates transient receptor potential …
AM 841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner
Background and Purpose Cannabinoid (CB) ligands have been demonstrated to have utility
as novel therapeutic agents for the treatment of pain, metabolic conditions and …
as novel therapeutic agents for the treatment of pain, metabolic conditions and …
The endocannabinoid system and its role in regulating the intrinsic neural circuitry of the gastrointestinal tract
SM Trautmann, KA Sharkey - International review of neurobiology, 2015 - Elsevier
Endocannabinoids are important neuromodulators in the central nervous system. They
regulate central transmission through pre-and postsynaptic actions on neurons and …
regulate central transmission through pre-and postsynaptic actions on neurons and …
Cannabinoid receptors in regulating the GI tract: experimental evidence and therapeutic relevance
U Taschler, C Hasenoehrl, M Storr… - Gastrointestinal …, 2017 - Springer
Cannabinoid receptors are fundamentally involved in all aspects of intestinal physiology,
such as motility, secretion, and epithelial barrier function. They are part of a broader entity …
such as motility, secretion, and epithelial barrier function. They are part of a broader entity …
Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases
R Schicho, M Storr - Canadian Journal of Gastroenterology and …, 2011 - Wiley Online Library
Many beneficial effects of herbal and synthetic cannabinoids on gut motility and
inflammation have been demonstrated, suggesting a vast potential for these compounds in …
inflammation have been demonstrated, suggesting a vast potential for these compounds in …