Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Abstract Calcium ion (Ca 2+) cycle plays a crucial role in the contraction and relaxation of
cardiomyocytes. The sarcoplasmic reticulum (SR) acts as an organelle for storing Ca 2+ …

Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality
and morbidity, and particularly to the risk of stroke in humans. Atrial-tissue fibrosis is a …

Background: The sarcoplasmic reticulum (SR) Ca2+-ATPase 2 (SERCA2) mediates Ca2+
reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine …

Background: Enhanced diastolic calcium (Ca2+) release through ryanodine receptor type-2
(RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic …

The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

Impaired transcription factor EB (TFEB) function and deficient autophagy activity have been
shown to aggravate intervertebral disc (IVD) degeneration (IDD), yet the underlying …

Abstract Calcium (Ca2+) ions are a key second messenger involved in the rhythmic
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …

Functional Proteomics aims to the identification of in vivo protein-protein interaction (PPI) in
order to piece together protein complexes, and therefore, cell pathways involved in …

Protein–protein interactions are essential for normal cellular processes and signaling
events. Defining these interaction networks is therefore crucial for understanding complex …