Opportunities and challenges in design and optimization of protein function
The field of protein design has made remarkable progress over the past decade. Historically,
the low reliability of purely structure-based design methods limited their application, but …
the low reliability of purely structure-based design methods limited their application, but …
[HTML][HTML] De novo protein design—From new structures to programmable functions
T Kortemme - Cell, 2024 - cell.com
Methods from artificial intelligence (AI) trained on large datasets of sequences and
structures can now" write" proteins with new shapes and molecular functions de novo …
structures can now" write" proteins with new shapes and molecular functions de novo …
The structural landscape of the immunoglobulin fold by large‐scale de novo design
J Roel‐Touris, L Carcelén, E Marcos - Protein Science, 2024 - Wiley Online Library
De novo designing immunoglobulin‐like frameworks that allow for functional loop
diversification shows great potential for crafting antibody‐like scaffolds with fully …
diversification shows great potential for crafting antibody‐like scaffolds with fully …
[HTML][HTML] Everything AlphaFold tells us about protein knots
Abstract Recent advances in Machine Learning methods in structural biology opened up
new perspectives for protein analysis. Utilizing these methods allows us to go beyond the …
new perspectives for protein analysis. Utilizing these methods allows us to go beyond the …