Although human mouth benefits from remarkable mechanical properties, it is very
susceptible to traumatic damages, exposure to microbial attacks, and congenital maladies …

Introduction Heart valve disease is a growing burden on the healthcare system. Current
solutions are insufficient for young patients and do not offer relief from reintervention. Tissue …

Soft porous materials, such as biological tissues and soils, are exposed to periodic
deformations in a variety of natural and industrial contexts. The detailed flow and mechanics …

Background Calcific aortic valve disease (CAVD) causes an increasing health burden in the
21st century due to aging population. The complex pathophysiology remains to be …

Heart valve disorders (HVD) caused by medical complications like calcification, thrombosis
and infective endocarditis are a reason for cardiac dysfunctionality. The main aim of the …

Elastic fibres play a key role in bodily functions where fatigue resistance and elastic recovery
are necessary while regulating phenotype, proliferation and migration in cells. While in vivo …

Purpose Tissue engineered heart valves (TEHV) are being investigated to address the
limitations of currently available valve prostheses. In order to advance a wide variety of …

A comprehensive introduction to nano-and biomaterials shining light on the different
research disciplines from various perspectives. The straightforward and well-structured …

Valvular heart disease is a major clinical challenge with significant morbidity and mortality
rate. Generally, valve repair is advantageous over replacement, however most of these …

One of the main challenges that have kept tissue-engineered constructs from being widely
adopted to clinics is poor cell survival due to limited mass transfer of oxygen and nutrients in …