Protein nanoparticles: uniting the power of proteins with engineering design approaches

N Habibi, A Mauser, Y Ko, J Lahann - Advanced Science, 2022 - Wiley Online Library
Protein nanoparticles, PNPs, have played a long‐standing role in food and industrial
applications. More recently, their potential in nanomedicine has been more widely pursued …

Bacterial iron detoxification at the molecular level

JM Bradley, DA Svistunenko, MT Wilson… - Journal of Biological …, 2020 - ASBMB
Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding

M Delarue, GP Brittingham, S Pfeffer, IV Surovtsev… - Cell, 2018 - cell.com
Macromolecular crowding has a profound impact on reaction rates and the physical
properties of the cell interior, but the mechanisms that regulate crowding are poorly …

Multiple origins of viral capsid proteins from cellular ancestors

M Krupovic, EV Koonin - Proceedings of the National …, 2017 - National Acad Sciences
Viruses are the most abundant biological entities on earth and show remarkable diversity of
genome sequences, replication and expression strategies, and virion structures …

A widespread bacterial protein compartment sequesters and stores elemental sulfur

R Benisch, MP Andreas, TW Giessen - Science Advances, 2024 - science.org
Subcellular compartments often serve to store nutrients or sequester labile or toxic
compounds. As bacteria mostly do not possess membrane-bound organelles, they often …

Large protein organelles form a new iron sequestration system with high storage capacity

TW Giessen, BJ Orlando, AA Verdegaal, MG Chambers… - Elife, 2019 - elifesciences.org
Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin
proteins are the major storage units for bioavailable forms of iron. Some organisms lack …

Structural basis of enzyme encapsulation into a bacterial nanocompartment

M Sutter, D Boehringer, S Gutmann… - Nature structural & …, 2008 - nature.com
Compartmentalization is an important organizational feature of life. It occurs at varying levels
of complexity ranging from eukaryotic organelles and the bacterial microcompartments, to …

Widespread distribution of encapsulin nanocompartments reveals functional diversity

TW Giessen, PA Silver - Nature microbiology, 2017 - nature.com
Cells organize and regulate their metabolism via membrane-or protein-bound organelles. In
this way, incompatible processes can be spatially separated and controlled. In prokaryotes …

Encapsulins

TW Giessen - Annual review of biochemistry, 2022 - annualreviews.org
Subcellular compartmentalization is a defining feature of all cells. In prokaryotes,
compartmentalization is generally achieved via protein-based strategies. The two main …

Structure unifies the viral universe

NGA Abrescia, DH Bamford, JM Grimes… - Annual review of …, 2012 - annualreviews.org
Is it possible to meaningfully comprehend the diversity of the viral world? We propose that it
is. This is based on the observation that, although there is immense genomic variation, every …