Chagas disease in the United States: a public health approach

C Bern, LA Messenger, JD Whitman… - Clinical microbiology …, 2019 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by
triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal …

The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications

B Zingales, MA Miles, DA Campbell… - Infection, genetics and …, 2012 - Elsevier
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Trypanosoma cruzi and Chagas' disease in the United States

C Bern, S Kjos, MJ Yabsley… - Clinical microbiology …, 2011 - Am Soc Microbiol
Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi and causes
potentially life-threatening disease of the heart and gastrointestinal tract. The southern half …

Over Six Thousand Trypanosoma cruzi Strains Classified into Discrete Typing Units (DTUs): Attempt at an Inventory

SF Brenière, E Waleckx, C Barnabé - PLoS neglected tropical …, 2016 - journals.plos.org
Trypanosoma cruzi, the causative agent of Chagas disease, presents wide genetic diversity.
Currently, six discrete typing units (DTUs), named TcI to TcVI, and a seventh one called …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Genetic diversity of Trypanosoma cruzi in bats, and multilocus phylogenetic and phylogeographical analyses supporting Tcbat as an independent DTU (discrete …

L Lima, O Espinosa-Álvarez, PA Ortiz, JA Trejo-Varón… - Acta tropica, 2015 - Elsevier
Trypanosoma cruzi is a complex of phenotypically and genetically diverse isolates
distributed in six discrete typing units (DTUs) designated as TcI–TcVI. Five years ago, T …

The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future

MA Miles, MS Llewellyn, MD Lewis, M Yeo, R Baleela… - Parasitology, 2009 - cambridge.org
Trypanosoma cruzi is the protozoan agent of Chagas disease, and the most important
parasitic disease in Latin America. Protozoa of the genus Leishmania are global agents of …

Reproductive clonality of pathogens: a perspective on pathogenic viruses, bacteria, fungi, and parasitic protozoa

M Tibayrenc, FJ Ayala - Proceedings of the National …, 2012 - National Acad Sciences
We propose that clonal evolution in micropathogens be defined as restrained recombination
on an evolutionary scale, with genetic exchange scarce enough to not break the prevalent …

Chagas Cardiomyopathy Manifestations and Trypanosoma cruzi Genotypes Circulating in Chronic Chagasic Patients

JD Ramírez, F Guhl, LM Rendón, F Rosas… - PLoS Neglected …, 2010 - journals.plos.org
Chagas disease caused by Trypanosoma cruzi is a complex disease that is endemic and an
important problem in public health in Latin America. The T. cruzi parasite is classified into six …

Recent, Independent and Anthropogenic Origins of Trypanosoma cruzi Hybrids

MD Lewis, MS Llewellyn, M Yeo, N Acosta… - PLoS neglected …, 2011 - journals.plos.org
The single celled eukaryote Trypanosoma cruzi, a parasite transmitted by numerous species
of triatomine bug in the Americas, causes Chagas disease in humans. T. cruzi generally …