Challenges and issues with streptozotocin-induced diabetes–a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics

SN Goyal, NM Reddy, KR Patil, KT Nakhate… - Chemico-biological …, 2016 - Elsevier
Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …

Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity

J Wu, LJ Yan - Diabetes, metabolic syndrome and obesity: targets …, 2015 - Taylor & Francis
Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …

Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide

P Masiello, C Broca, R Gross, M Roye… - Diabetes, 1998 - Am Diabetes Assoc
We took advantage of the partial protection exerted by suitable dosages of nicotinamide
against the β-cytotoxic effect of streptozotocin (STZ) to create a new experimental diabetic …

Streptozotocin‐induced diabetes models: Pathophysiological mechanisms and fetal outcomes

DC Damasceno, AO Netto, IL Iessi… - BioMed research …, 2014 - Wiley Online Library
Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic
disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present …

Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on β-cells of pancreas

N Fatima, RM Hafizur, A Hameed, S Ahmed… - European journal of …, 2017 - Springer
Purpose The present study was undertaken to explore the possible anti-diabetic mechanism
(s) of Emblica officinalis (EO) and its active constituent, ellagic acid (EA), in vitro and in vivo …

Glucagon-like peptide-1 and exendin-4 stimulate β-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at …

C Tourrel, D Bailbe, MJ Meile, M Kergoat, B Portha - Diabetes, 2001 - Am Diabetes Assoc
In neonatal Wistar rats injected with streptozotocin (STZ) at birth (n0-STZ model), a
recognized model of β-cell regeneration, we investigated the capacity of early treatment with …

Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models

A Okyar, A Can, N Akev, G Baktir… - Phytotherapy …, 2001 - Wiley Online Library
Abstract Aloe vera (L.) Burm. fil.(= A. barbadensis Miller)(Liliaceae) is native to North Africa
and also cultivated in Turkey. Aloes have long been used all over the world for their various …

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function.

DL Eizirik, GS Korbutt… - The Journal of clinical …, 1992 - Am Soc Clin Investig
The aim of the present study was to clarify whether prolonged in vitro exposure of human
pancreatic islets to high glucose concentrations impairs the function of these cells. For this …

Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats

M Tabuchi, M Ozaki, A Tamura, N Yamada… - Bioscience …, 2003 - jstage.jst.go.jp
Neonatally streptozotocin-induced diabetic (n-STZ) rats were given food containing
Lactobacillus GG cells (GG) or a control diet (control), from 9 to 18 weeks of age. The GG …

[HTML][HTML] Processed meat intake and incidence of Type 2 diabetes in younger and middle-aged women

MB Schulze, JE Manson, WC Willett, FB Hu - Diabetologia, 2003 - Springer
Aim/hypothesis The aim of this study was to investigate the association between processed
and other meat intake and incidence of Type 2 diabetes in a large cohort of women …