Insertion sequences (ISs), arguably the smallest and most numerous autonomous
transposable elements (TEs), are important players in shaping their host genomes. This …

Insertion sequences (ISs) constitute an important component of most bacterial genomes.
Over 500 individual ISs have been described in the literature to date, and many more are …

The transposon Tn21 and a group of closely related transposons (the Tn21 family) are
involved in the global dissemination of antibiotic resistance determinants in gram-negative …

Retroviral DNA integration involves a coordinated set of DNA cutting and jolning reactions.
Linear viral DNA is cleaved at each 3'end to generate the precursor ends for integration. The …

We have divided this review into two major sections. In one, we have attempted to present
an overview of our current understanding of prokaryotic insertion sequences (IS), their …

HIV integrase is the enzyme responsible for inserting the viral DNA into the host
chromosome; it is essential for HIV replication. The crystal structure of the catalytically active …

Our comparison of deduced amino acid sequences for retroviral/retrotransposon integrase
(IN) proteins of several organisms, including Drosophila melanogaster and …

The integration of a DNA copy of the human immunodeficiency virus type 1 (HIV-1) genome
into a chromosome of an infected cell is a pivotal step in virus replication. Integration …

We have probed the structural organization of the human immunodeficiency virus type 1
integrase protein by limited proteolysis and the functional organization by site-directed …

Early after infection, the retroviral RNA genome is reverse transcribed to generate a linear
cDNA copy, then that copy is integrated into a chromosome of the host cell. We report that …